Adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual-source computed tomography: Concepts and first experiences

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• 作者：Gorka Bastarrika ; MD ; PhD^a ; ^b ; Luis Ramos-Duran ; MD^a ; U. Joseph Schoepf ; MD^a ; ^c ; ^{schoepf@musc.edu} ; Michael A. Rosenblum ; MD^c ; Joseph A. Abro ; MA^a ; Robin L. Brothers ; RT^a ; José ; L. Zubieta ; MD ; PhD^b ; Salvatore A. Chiaramida ; MD^c ; Doo Kyoung Kang ; MD^a ; ^d
• 关键词：Angiography ; Cardiac function ; Computed tomography ; Coronary vessels ; Myocardial perfusion
• 刊名：Journal of Cardiovascular Computed Tomography
• 出版年：2010
• 出版时间：March-April 2010
• 年：2010
• 卷：4
• 期：2
• 页码：127-135
• 全文大小：1167 K

文摘

Recent research suggests that multidetector-row CT may have potential as a standalone modality for integrative imaging of coronary heart disease, including the assessment of the myocardial blood supply. However, the technical prerequisites for volumetric, time-resolved imaging of the passage of a contrast medium bolus through the myocardium have only been met with latest generation wide-detector CT scanners. Second-generation dual-source CT enables performing electrocardiographic (ECG)¨Csynchronized dynamic myocardial perfusion imaging by a dedicated ¡°shuttle?mode. With this acquisition mode, image data can be acquired during contrast medium infusion at 2 alternating table positions with the table shuttling back and forth between the 2 positions covering a 73-mm anatomic volume. We applied this acquisition technique for detecting differences in perfusion patterns between healthy and diseased myocardium and for quantifying myocardial blood flow under adenosine stress in 3 patients with coronary heart disease. According to our initial experience, the addition of adenosine stress volumetric dynamic CT perfusion to a cardiac CT protocol comprising coronary artery calcium quantification, prospectively ECG-triggered coronary CT angiography, and delayed acquisition appears promising for the comprehensive assessment of coronary artery luminal integrity, cardiac function, perfusion, and viability with a single modality.