Paraneoplastic cerebellar degeneration with anti-Yo antibodies associated with metastatic uveal melanoma
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- 作者：Sara Valpione ; Marco Zoccarato ; Raffaele Parrozzani ; Jacopo Pigozzo ; Bruno Giometto ; Francesco Laveder ; Camillo Aliberti ; Vanna Chiarion-Sileni
- 关键词：Uveal melanoma ; Paraneoplastic cerebellar degeneration ; Anti-Yo antibodies ; Paraneoplastic syndrome ; Cancer ; CDR2
- 刊名：Journal of the Neurological Sciences
- 出版年：15 December, 2013
- 年：2013
- 卷：335
- 期：1-2
- 页码：210-212
- 全文大小：262 K
文摘
Paraneoplastic cerebellar degeneration (PCD) is characterized by subacute development of pancerebellar dysfunction as a remote effect of a systemic cancer and usually develops in patients affected by gynecological tumors. Uveal melanoma is a very rare disease with a severe prognosis.
A 58-year-old man affected by uveal melanoma developed anti-Yo positive paraneoplastic cerebellar degeneration (PCD) 42 months after the initial diagnosis. The onset and worsening of the neurological symptoms were parallel to the course of liver metastasis.
To our knowledge this is the first case of PCD in a patient with uveal melanoma. We speculate that the cerebellar degeneration-related protein 2 (CDR2), to which the anti-Yo antibodies are directed, may have been expressed in melanoma cells and conferred proliferative advantage to the disease.