Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension

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• 作者：Seiichiro Sakaoup>aup>up> ; up>up>1up>up> ; up>up>sakaos@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Michiko Daimonup>bup>up> ; up>up>1up>up> ; up>up>miko0122@kkd.biglobe.ne.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Norbert F. Voelkelup>eup>up> ; up>up>nfvoelkel@gmail.com" class="auth_mail" title="E-mail the corresponding authorup> ; Hideyuki Miyauchiup>bup>up> ; up>up>hmiyauchi_circ@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Takayuki Jujoup>cup>up> ; up>up>naikamo_resp19184@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Toshihiko Sugiuraup>aup>up> ; up>up>sugiura@js3.so-net.ne.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Keiichi Ishidaup>dup>up> ; up>up>keiichi-ishida@pro.odn.ne.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Nobuhiro Tanabeup>cup>up> ; up>up>ntanabe@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding authorup> ; Yoshio Kobayashiup>bup>up> ; up>up>yuiryosuke@msn.com" class="auth_mail" title="E-mail the corresponding authorup> ; Koichiro Tatsumiup>aup>up> ; up>up>tatsumi@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding authorup>
• 关键词：Pulmonary hypertension ; Right ventricle ; Glucose oxidation ; Glycolysis ; Fatty acid oxidation
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：219
• 期：Complete
• 页码：143-149
• 全文大小：924 K

文摘

Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension. The aims of this study are to assess right ventricular glucose and fatty acid in chronic thromboembolic pulmonary hypertension (CTEPH) patients before and after pulmonary thromboendarterectomy and to examine whether there is a correlation between right ventricular glucose and fatty acid uptake.

Methods

To assess glucose and fatty acid accumulation in the RV, [up>18up>F] fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) and up>123up>I-β-methyl iodophenyl pentadecanoic acid (BMIPP) imaging were performed in CTEPH patients before (FDG: n = 20, BMIPP: n = 13) and after (FDG: n = 12, BMIPP: n = 8) thromboendarterectomy.

Results

Both [up>18up>F] FDG uptake and up>123up>I-BMIPP uptake in RV of post-PEA patients obviously decreased after this operation procedure (p < 0.01). The right ventricle [up>18up>F] FDG uptake was also significantly correlated with up>123up>I-BMIPP uptake (r = 0.45, p = 0.04).

Conclusions

In this study, we observed that both glucose and fatty acid accumulated in the RV of patients with CTEPH. Although the exact details of the altered energy metabolism in the stressed RV remain unknown, this is the first study to evaluate both glucose and fatty acid uptake before and after thromboendarterectomy in patients with CTEPH, even though the number of the patient is limited.