Dietary fish oil normalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation, peroxisome proliferator-activated receptor ¦Ã and uncoupling protein 2

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• 作者：M.R. Ferreira ; A. Chicco ; Y.B. Lombardo
• 关键词：Fish oil ; Glucose-stimulated insulin secretion ; Dyslipemic rats ; Pancreatic islets ; PPARs ; UCP2
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：89
• 期：1
• 页码：31-38
• 全文大小：443 K

文摘

This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on ¦Â cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor ¦Ã (PPAR¦Ã) and uncoupling protein 2 without changes in GLUT2 and PPAR¦Á. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.