Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads
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- 作者：Nan Miao ; Xin Wang ; Yue Hou ; Yanping Feng ; fengyanping594@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yanzhang Gong ; poultry@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chicken ; Sex-biased miRNAs ; miR-107 ; Gonadal development ; NR5a1
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 July 2016
- 年：2016
- 卷：429
- 期：Complete
- 页码：29-40
- 全文大小：4109 K
文摘
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Sex-biased miRNAs were validated in expression profiles of E5.5 Chicken gonads.
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Several sex-biased miRNAs might play roles in gonadogenesis through their targets.
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MiR-107 directly inhibited NR5a1 and CYP19A1 but did not target AMH.
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MiR-107 specifically regulated ovary-development at post-transcriptional level.