Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabled
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- 作者：Aaron S. Kemp ; Paul T. Fillmore ; Mohammed R. Lenjavi ; Melvin Lyon ; Aleks ; ra Chicz-DeMet ; Paul E. Touchette ; Curt A. S ; man
- 关键词：Self-injurious behavior ; Developmental disabilities ; Temporal pattern analysis ; Proopiomelanocortin ; ACTH ; β ; -Endorphin
- 刊名：Psychiatry Research
- 出版年：2008
- 出版时间：15 January 2008
- 年：2008
- 卷：157
- 期：1-3
- 页码：181-189
- 全文大小：253 K
文摘
While the origins and developmental course of self-injurious behavior (SIB) remain relatively unknown, recent studies suggest a biological imbalance may potentiate or provoke the contagious recurrence of SIB patterns in individuals with severe developmental disabilities (DD). Evidence from several laboratories indicates that functioning, relations, and processing of a stress-related molecule, proopiomelanocortin (POMC) may be perturbed among certain subgroups of individuals exhibiting SIB. The current investigation employed a unique time-pattern analysis program (THEME) to examine whether recurrent temporal patterns (T-patterns) of SIB were related to morning levels of two POMC-derived hormones: β-endorphin (βE) and adrenocorticotropic hormone (ACTH). THEME was used to quantify highly significant (non-random) T-patterns that included SIB within a dataset of in situ observational recordings spanning 8 days (![]()
40 h) in 25 subjects with DD. Pearson's product–moment analyses revealed highly significant correlations between the percentage of T-patterns containing SIB and basal levels of both βE and ACTH, which were not found with any other “control” T-patterns. These findings support the hypothesis that the recurrent temporal patterning of SIB represents a unique behavioral phenotype directly related to perturbed levels of POMC-derived stress hormones in certain individuals with severe DD.