Role of testosterone in regulating induction of TNF-α in rat spleen via ERK signaling pathway
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- 作者：Chien-Wei Chena ; Cai-Yun Jiana ; Po-Han Lina ; Chih-Chieh Chena ; Fu-Kong Lieub ; Christina Soongb ; Chu-Chun Hsieha ; Chi-Yun Wana ; Galina Idovai ; Sindy Hug ; h ; Shyi-Wu Wangc ; g ; 1 ; swwang@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Paulus S. Wanga ; d ; e ; f ; 1 ; pswang@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Testosterone ; Orchidectomy ; Splenocyte ; Inflammation ; TNF-α
- 刊名：Steroids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：148-154
- 全文大小：1024 K
文摘
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Testosterone withdrawal is associated with strong inflammation.
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Orchidectomy triggers NO production and LPS-evoked TNF-α secretion ex vivo.
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p-ERK protein expression was markedly enhanced on orchidectomized rats.
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Orchidectomy resulted in splenomegaly and promoted splenocyte proliferation rate.
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Testosterone attenuated inflammatory molecules secretion in vitro.