Effects of diet containing monosodium glutamate on organ weights, acute blood steroidal sex hormone levels, lipid profile and erythrocyte antioxidant enzymes activities of rats

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• 作者：Chiedozie Onyejiaka Ibegbulem¹ ; Paul Chidoka Chikezie² ; ^{p_chikezie@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Agwu Igwe Ukoha¹ ; Chinwe Ngozi Opara¹
• 关键词：Estradiol ; Monosodium glutamate ; Serum lipid profile ; Testosterone
• 刊名：Journal of Acute Disease
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：5
• 期：5
• 页码：402-407
• 全文大小：435 K

文摘

To study the effects of diet containing monosodium glutamate on visceral organ weights, acute blood steroidal sex hormone levels, serum lipid profile (SLP) and erythrocyte antioxidant enzymes activities of Wistar rats.

Methods

The Wistar rats were grouped into two groups of six rats each. The ones in Group 1 (control group) were placed on water and pelletized standard guinea feed ad libitum, whereas Group 2 was regarded as test group [Wistar rats (WR)-monosodium glutamate (MSG) group] and the Wistar rats received water, compounded diet of MSG and pelletized standard guinea feed ad libitum. After 33 days of feeding study, rat body weight was obtained. Rats were sacrificed and the incisions were made into the thoracic cavity and blood samples were drawn by cardiac puncture as a terminal event. Plasma was assayed for estradiol and testosterone concentrations, SLP and erythrocyte peroxidase and catalase activities. Visceral organ weights were also measured.

Results

WR-MSG exhibited marginal alterations in blood estradiol and testosterone concentrations. Elevation of serum triacylglycerol concentration in WR-MSG was corresponded to 77.7%. Increases in serum concentrations of very low-density lipoprotein cholesterol and low-density lipoprotein cholesterol in WR-MSG were corresponded to 70.6% and 41.0% respectively. Erythrocyte peroxidase and catalase activities showed marginal alterations. Alterations in visceral organs-to-body weights ratios were not profound.

Conclusions

Blood testosterone and estradiol concentrations were not significantly (P > 0.05) altered, which may not be connected with the low dose of MSG in the diet. Marginal alterations of SLP did not indicate atherogenicity in WR-MSG. The visceral organs were not atrophic or hypertrophic because of the comparatively low dose of MSG consumed by WR-MSG and the duration of the feeding experiment.