let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex
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- 作者：Tsai-Tsen Liao1 ; Wen-Hao Hsu1 ; Chien-Hsin Ho1 ; Wei-Lun Hwang7 ; Hsin-Yi Lan1 ; Ting Lo1 ; Cheng-Chi Chang8 ; Shyh-Kuan Tai2 ; Muh-Hwa Yang1 ; 3 ; 4 ; 5 ; 6 ; mhyang2@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：520-533
- 全文大小：3877 K
文摘
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let-7 regulates multiple steps in biogenesis of the ARID3B-ARID3A complex
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ARID3B complex recruits KDM4C for H3K9me3 demethylation at target genes
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ARID3B complex regulates the expression of stemness genes and let-7 target genes
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let-7-ARID3B axis is a prognostic indicator in human cancers