lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

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• 作者：Chikara Meno ; Akihiko Shimono ; Yukio Saijoh ; Kenta Yashiro ; Kyoko Mochida ; Sachiko Ohishi ; Sumihare Noji ; Hisato Kondoh ; Hiroshi Hamada
• 刊名：Cell
• 出版年：1998
• 出版时间：7 August 1998
• 年：1998
• 卷：94
• 期：3
• 页码：287-297
• 全文大小：638 K

文摘

lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1–deficient mice showed a variety of L-R positional defects in visceral organs. Unexpectedly, however, the most common feature of lefty-1^−/− mice was thoracic left isomerism (rather than right isomerism). The lack of lefty-1 resulted in bilateral expression of nodal, lefty-2, and Pitx2 (a homeobox gene normally expressed on the left side). These observations suggest that the role of lefty-1 is to restrict the expression of lefty-2 and nodal to the left side, and that lefty-2 or nodal encodes a signal for “leftness.”