Correlation of phylogenetic clade diversification and in vitro infectivity differences among Cosmopolitan genotype strains of Chikungunya virus
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- 作者：Rachy Abrahama ; Anoop Manakkadana ; 1 ; Prashant Mudaliara ; Iype Josephb ; Krishnankutty Chandrika Sivakumarc ; Radhakrishnan Reghunathan Naird ; Easwaran Sreekumara ; esreekumar@rgcb.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chikungunya ; Bayesian analysis ; Mammalian cell ; Infection kinetics
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：174-184
- 全文大小：1796 K
文摘
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Identified genetic clade diversification of Cosmopolitan genotype Chikungunya virus strains
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Detected correlation between genetic clade diversification and enhanced mammalian cell infectivity
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Identified novel mutations in viral strains with higher infectivity
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Detected a novel E2 K252H mutation in recent (2012–13) strains