Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo
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- 作者：Hussin A. Rothana ; rothan@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Hirbod Bahrania ; hirbodb83@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ammar Y. Abdulrahmana ; alirhayim83@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zulqarnain Mohamedb ; zulq@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Teow Chong Teohb ; ttchong@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Shatrah Othmana ; shatraho@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Nurshamimi Nor Rashida ; nurshamimi@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Noorsaadah A. Rahmanc ; noorsaadah@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Rohana Yusofa ; rohana@um.edu.my" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chikungunya virus ; Non-steroidal anti-inflammatory drugs ; Mefenamic acid ; Meclofenamic acid ; Ribavirin
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：50-56
- 全文大小：880 K
文摘
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Mefenamic acid and Meclofenamic acid can inhibit CHIKV replication.
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Mefenamic acid can bind with viral protease.
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The combination of Mefenamic acid with ribavirin attenuated CHIKV infection in vivo.