- 作者：Antonio Carlos Bandeira ; MD MPHa ; antoniobandeira@gmail.com" class="auth_mail" title="E-mail the corresponding author (Infectious Diseases Associate Professor) ; Gubio Soares Campos ; Ph.D.b ; gubiosoares@gmail.com" class="auth_mail" title="E-mail the corresponding author (Head) ; Silvia Ines Sardi ; Ph.D.b ; sissardi@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Veronica Franç ; a Diniz Rocha ; MDc ; veronica.diniz.rocha@gmail.com" class="auth_mail" title="E-mail the corresponding author (Hospital Infection Control Committee) ; Guilherme Cesar Mendes Rocha ; MDd ; guilhermecmrocha@uol.com.br" class="auth_mail" title="E-mail the corresponding author (Neuroradiologist)
- 关键词：Chikungunya-associated encephalitis ; Chikungunya neonatal ; Neurological syndromes ; Neonatal encephalitis ; Vertical transmission.
- 刊名：IDCases
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：57-59
- 全文大小：422 K
Methods
Case report.
Results
A male neonate with 3500 g developed macular erythematous rash, hypoactivity and fever progressing to generalized seizures. His mother had experienced a disseminated rash and fever before delivery. EEG showed diffuse slowing and cranial NMR was suggestive of encephalitis. Rt-PCR for Chikungunya virus (CHIKV) was positive in cerebrospinal fluid (CSF), blood, urine and saliva. The newborn was discharged home with neurological improvement.
Conclusion
We report the first case of a perinatal CHIKV infection associated with a rapidly evolving encephalitis and an extensive dissemination of the virus as documented by positive rt-PCR results in CSF, blood, urine and saliva in the present outbreak in Brazil. In countries experiencing outbreaks of CHIKV infections, clinicians and neonatologists must be familiar with the possibility of the occurrence of neurologic complications and its possible consequences.