Ethnic Minorities Are at Greater Risk for Childhood-Onset Type 2 Diabetes and Poorer Glycemic Control in England and Wales

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• 作者：Amal R. Khanolkar ; Ph.D.^a ; ^b ; ^{a.khanolkar@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Rakesh Amin ; M.D.^a ; David Taylor-Robinson ; Ph.D.^a ; ^c ; Russell Viner ; Ph.D.^a ; Justin Warner ; M.D.^d ; ¹ ; Terence Stephenson ; D.M.^a
• 关键词：Type 2 diabetes ; Ethnicity ; Glycemic control ; HbA1c ; Childhood ; Adolescence ; Prevalence ; England ; Wales
• 刊名：Journal of Adolescent Health
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：59
• 期：3
• 页码：354-361
• 全文大小：570 K

文摘

Ethnic minority children are at a greater risk for type 2 diabetes (T2D). However, current prevalence of T2D among children and young people is unknown in England and Wales. In addition, little is known on glycemic control in pediatric T2D globally.

Methods

Using data from the National Paediatric Diabetes Audit for 2012–2013 with >98% coverage of diabetes cases, we estimated (1) the overall, gender- and ethnic-specific prevalence of T2D in children and young people <16 years and (2) whether ethnicity predicts glycemic control (measured by mean HbA_1c) in children and young people <19 years. Ethnicity was self-identified and categorized into white, Asian, black, mixed, other, and “not stated.” Multivariable linear regression was used to estimate differences in glycemic control by ethnicity adjusting for socioeconomic status, age, diabetes duration, and gender.

Results

A total of 307 children and young people aged <16 years were identified with T2D in the National Paediatric Diabetes Audit for 2012–2013. Overall prevalence of T2D was 2.9/100,000. Females had a higher prevalence of T2D than males (4.3 vs. 1.5/100,000). The highest prevalence was found in Asian (12.2/100,000) followed by mixed ethnicity (4.4/100,000) females. Children of mixed ethnicity had significantly higher mean HbA_1c compared with white children (9.7% [83 mmol/mol] vs. 7.8% [62 mmol/mol], p < .001, and adjusted mean difference of 4.2% [22.3 mmol/mol], 95% confidence interval = 3.1%–5.2% [10.9–33.7 mmol/mol]), but there were no significant differences between the other ethnic minority groups.

Conclusions

Children of all ethnic minorities particularly females have an increased prevalence of T2D. Those belonging to mixed ethnic backgrounds are at increased risk for poorer glycemic control.