Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma

详细信息    查看全文

• 作者：Rosemary Rochford ^{rosemary.rochford@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author empanana@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Epstein-Barr virus ; Burkitt lymphoma ; Plasmodium falciparum ; Malaria ; Activation induced cytidine deaminase
• 刊名：Boletín Médico del Hospital Infantil de México
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：73
• 期：1
• 页码：41-46
• 全文大小：1170 K

文摘

Since its first description by Denis Burkitt, endemic Burkitt's lymphoma (BL), the most common childhood cancer in sub-Saharan Africa, has led scientists to search for clues to the origins of this malignancy. The discovery of Epstein-Barr virus (EBV) in BL cells over 50 years ago led to extensive sero-epidemiology studies and revealed that rather than being a virus restricted to areas where BL is endemic, EBV is ubiquitous in the world's population with an estimated greater than 90% of adults worldwide infected. A second pathogen, Plasmodium falciparum (P. falciparum) malaria is also linked to BL. In this review, we will discuss recent studies that indicate a role for P. falciparum malaria in dysregulating EBV infection, and increasing the risk for BL in children living where P. falciparum malaria transmission is high.