Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children

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• 作者：Sheikh F. Ahmad^a ; ^{fashaikh@ksu.edu.sa} ; ^{s_fayazahmad@yahoo.com} ; Ahmed Nadeem^a ; Mushtaq A. Ansari^a ; Saleh A. Bakheet^a ; Sabry M. Attia^a ; ^b ; Khairy M.A. Zoheir^a ; ^c ; Laila Yousef AL-Ayadhi^d ; Mohammad Z. Alzahrani^a ; Abdulaziz M.S. Alsaad^a ; Moureq R. Alotaibi^a ; Adel R.A. Abd-Allah^b
• 关键词：Children with autism ; Typically developing children ; Peripheral blood mononuclear cells (PBMCs) ; Cytokines ; CD152 (CTLA-4)
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：57-65
• 全文大小：1989 K
• 卷排序：82

文摘

Enhanced pro-inflammatory cytokine production (IL-21/IL-22) on PBMC in AU. Decreased anti-inflammatory molecules (IL-27/CTLA-4) on PBMC in AU. Induction of IL-21/IL-22 protein and mRNA expression in AU children. Decreased IL-27 mRNA expression in children with AU.