The PDLIM5 gene and lithium prophylaxis: An association and gene expression analysis in Sardinian patients with bipolar disorder

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• 作者：Alessio Squassina ; Donatella Congiu ; Francesca Manconi ; Mirko Manchia ; Caterina Chillotti ; Simona Lampus ; Giovanni Severino ; Maria Del Zompo
• 关键词：Lithium therapy ; Bipolar disorder ; PDLIM5 expression ; Sardinia
• 刊名：Pharmacological Research
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：57
• 期：5
• 页码：369-373
• 全文大小：182 K

文摘

A number of studies support the notion that lithium interacts with the protein kinase C (PKC) pathway, an important mediator of several intracellular responses to neurotransmitter signaling. PDLIM5 (PDZ and LIM domain 5; LIM) is an adaptor protein that selectively binds the isozyme PKC to N-type Ca²⁺ channels in neurons. We tested for an association between three single nucleotide polymorphisms (SNPs) at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium. In order to evaluate whether PDLIM5 expression interacts with lithium response, we carried out gene expression analysis in lymphoblastoid cells of 30 bipolar patients. No association was shown between PDLIM5 polymorphisms and lithium response. When PDLIM5 expression was evaluated, no significant differences were detected between Full Responders to lithium (total score ≥ 7) and other patients (total score ≤ 6). Our negative findings do not exclude involvement of PDLIM5 in lithium prophylaxis, and further investigation is warranted.