Genome sequence of foot-and-mouth disease virus outside the 3A region is also responsible for virus replication in bovine cells
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- 作者：Xueqing Maa ; Pinghua Lia ; Pu Suna ; Zengjun Lua ; Huifang Baoa ; Xingwen Baia ; Yuanfang Fua ; Yimei Caoa ; Dong Lia ; Yingli Chena ; Zilin Qiaob ; Zaixin Liua ; liuzaixin@caas.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Foot-and-mouth disease virus ; 3A ; Host range
- 刊名：Virus Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：220
- 期：Complete
- 页码：64-69
- 全文大小：1383 K
文摘
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We generate two chimeric viruses with the 3A region of O/HKN/21/70.
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The chimeric viruses stably maintained the foreign gene after passage in BHK-21 cells.
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The 3A region was not the only genetic determinant affecting FMDV replication in FBK cells.
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FMDV genome sequence outside the 3A region also affect FMDV replication in FBK cells.