Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy
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- 作者：Ulrike Mock1 ; * ; Lauren Nickolay1 ; * ; l.nickoay@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Brian Philip2 ; Gordon Weng-Kit Cheung2 ; Hong Zhan1 ; Ian C.D. Johnston3 ; Andrew D. Kaiser3 ; Karl Peggs2 ; Martin Pule2 ; Adrian J. Thrasher1 ; Waseem Qasim1
- 关键词：automation ; CAR19 ; chimeric antigen receptors ; CliniMACS prodigy ; GMP ; immunotherapy ; T-cell transduction ; T cells
- 刊名：Cytotherapy
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：18
- 期：8
- 页码：1002-1011
- 全文大小：1811 K
文摘
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In this study, we demonstrated the feasibility of CliniMACS Prodigy for T-cell transduction.
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We studied the successful automated generation of CD19-CAR+ T cells in clinically relevant doses.
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We sought confirmation of in vitro and in vivo efficacy of automatically generated product.