Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China

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• 作者：Wen Jiao YIN^aAuthor Vitae ; Li Ping SHEN^a ; Fu Zhen WANG^b ; Guo Min ZHANG^b ; Hui ZHENG^b ; Feng WANG^a ; Tie Zhu LIU^a ; Qing Ling MENG^a ; Yao YI^a ; Fu Qiang CUI^b ; ^{cuifuq@126.com} ; Sheng Li BI^a ; ^{shengli_bi@163.com}
• 关键词：Mother-to-infant transmission ; Scheduled vaccination ; Gene characteristics ; &lsquo ; a&rsquo ; determinant mutation ; Immune escape
• 刊名：Biomedical and Environmental Sciences
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：29
• 期：11
• 页码：790-801
• 全文大小：1372 K
• 卷排序：29

文摘

To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus (HBV) infected mothers and to characterize HBV genes.MethodsHBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software.ResultsThe immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% (32/556). High sequence homology (99.8%-100%) was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype C1 strains. Three serotypes were detected: adr (19/30), adw (9/30), and ayw (2/30). The frequency of amino acid mutation of the ‘a’ determinant region was 16.67% (5/30), including that of Q129H, F134Y, S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome.ConclusionThe immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ‘a’ determinant region could not account for immunoprophylactic failure for all infants.