Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with β-casein expression in mammary epithelial cells
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- 作者：Ken Kobayashi ; kkobaya@anim.agr.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yusaku Tsugami ; Kota Matsunaga ; Shoko Oyama ; Chinatsu Kuki ; Haruto Kumura
- 关键词：Prolactin ; Glucocorticoid ; Tight junction ; Mammary gland ; Epithelial cell
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1863
- 期：8
- 页码：2006-2016
- 全文大小：3687 K
文摘
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Prolactin signaling downregulates Claudin-3 and-4 with low β-casein expression.
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Glucocorticoid signaling upregulates Claudin-3 and -4 without β-casein expression.
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Prolactin and glucocorticoid signaling specifically downregulates Claudin-4.
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Prolactin and glucocorticoid signaling induce lactation-specific tight junctions.
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Prolactin and glucocorticoid signaling synergistically upregulate β-casein expression.