Curcumin protects retinal cells from light-and oxidant stress-induced cell death
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- 作者：Md Nawajes A. M ; al ; Jagan M.R. Patlolla ; Lixin Zheng ; Martin-Paul Agbaga ; Julie-Thu A. Tran ; Lea Wicker ; Anne Kasus-Jacobi ; Michael H. Elliott ; Chinthalapally V. Rao ; Robert E. Anderson
- 关键词：Curcumin ; AMD ; Light-induced retinal degeneration ; Photoreceptors ; Retina
- 刊名：Free Radical Biology and Medicine
- 出版年：2009
- 出版时间：1 March 2009
- 年：2009
- 卷：46
- 期：5
- 页码：672-679
- 全文大小：585 K
文摘
Age-related macular degeneration (AMD) is a complex disease that has potential involvement of inflammatory and oxidative stress-related pathways in its pathogenesis. In search of effective therapeutic agents, we tested curcumin, a naturally occurring compound with known anti-inflammatory and antioxidative properties, in a rat model of light-induced retinal degeneration (LIRD) and in retina-derived cell lines. We hypothesized that any compound effective against LIRD, which involves significant oxidative stress and inflammation, would be a candidate for further characterization for its potential application in AMD. We observed significant retinal neuroprotection in rats fed diets supplemented with curcumin (0.2 % in diet) for 2 weeks. The mechanism of retinal protection from LIRD by curcumin involves inhibition of NF-κB activation and down-regulation of cellular inflammatory genes. When tested on retina-derived cell lines (661W and ARPE-19), pretreatment of curcumin protected these cells from H2O2-induced cell death by up-regulating cellular protective enzymes, such as HO-1, thioredoxin. Since, curcumin with its pleiotropic activities can modulate the expression and activation of many cellular regulatory proteins such as NF-κB, AKT, NRF2, and growth factors, which in turn inhibit cellular inflammatory responses and protect cells; we speculate that curcumin would be an effective nutraceutical compound for preventive and augmentative therapy of AMD.