Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome

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• 作者：Alex Bittner ; Herná ; n Alcaí ; no ; Pablo F. Castro ; Osvaldo Pé ; rez ; Ramó ; n Corbalá ; n ; Rodrigo Troncoso ; Mario Chiong ; Rosemarie Mellado ; Francisco Moraga ; Diego Zanolli ; José ; L.
• 关键词：Metalloproteinases ; MMP-9 ; Oxidative stress ; Acute coronary syndrome ; Inflammation
• 刊名：International Journal of Cardiology
• 出版年：2010
• 出版时间：6 August 2010
• 年：2010
• 卷：143
• 期：1
• 页码：98-100
• 全文大小：96 K

文摘

In the present work we evaluate the relationship between oxidative stress and matrix metalloproteinases-2 and -9 (MMP-2 and -9) activities in 44 patients with non ST-elevation acute coronary syndrome. We found an early increase in malondialdehyde (MDA) levels (oxidative stress marker) and MMP-9, with decrease of both at day five. A positive correlation was found between fractional changes of MDA and MMP-9, suggesting a common role in the pathophysiology of the acute coronary syndrome.