Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-纬
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- 作者：Chia-Ling Chena ; Tzu-Hui Chiangb ; Po-Chun Tsengb ; Yu-Chih Wangc ; Chiou-Feng Linc ; d ; cflin2014@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTEN ; IFN-纬 ; ROS ; SHP2 ; Signaling
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：23 October 2015
- 年：2015
- 卷：466
- 期：3
- 页码：578-584
- 全文大小：1215 K
文摘
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This study demonstrates that PTEN decrease causes cellular unresponsive to IFN-纬.
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Lung cancer cells with PTEN deficiency show unresponsive to IFN-纬 signaling.
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PTEN decrease inhibits IFN-纬-induced CD54, cell proliferation inhibition, and cytotoxicity.
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ROS-mediated SHP2 activation makes PTEN-deficient cells unresponsive to IFN-纬.