Regioselective synthesis of 3-benzyl substituted pyrimidino chromen-2-ones and evaluation of anti-microbial and anti-biofilm activities
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- 作者：Narender Reddy Emmadi ; Krishnaiah Atmakur ; Chiranjeevi Bingi ; Narender Reddy Godumagadda ; Ganesh Kumar Chityal ; Jagadeesh Babu Nanubolu
- 关键词：6-Amino uracil ; 4-Hydroxy coumarin ; Aldehydes ; 3-Benzyl substituted pyrimidino chromen-2-ones
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：15 January, 2014
- 年：2014
- 卷：24
- 期：2
- 页码：485-489
- 全文大小：2143 K
文摘
Regioselective synthesis of a number of highly functionalized 3-benzylpyrimidino chromen-2-ones (4) were accomplished in a one pot three component reaction in acetic acid and determined their anti-microbial and anti-biofilm activities. Compounds 4o and 4p showed an excellent anti-microbial activity against Micrococcus luteus MTCC 2470 at a par with standard control (Ciprofloxacin) and exhibited best activity against Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 121. Further, compounds 4h, 4i, 4m, 4n and 4q showed promising activity against Micrococcus luteus MTCC 2470, Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 121. Whereas, compounds 4m showed very promising biofilm inhibition activity against Staphylococcus aureus MLS 16 MTCC 2940 and 4o, 4p showed very potent activity against Staphylococcus aureus MTCC 96 at a par with Ciprofloxacin used as standard control.