Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging
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- 作者：Nioka C. Chisholm ; Farida Sohrabji ; sohrabji@medicine.tamhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Astrocyte ; Stroke ; Hormones ; Estrogen ; Progesterone ; Glutamate ; Excitotoxicity ; Neuroinflammation ; IGF-1 ; VEGF ; MicroRNA ; Epigenetics ; HDAC ; H3K4me3 ; Methylation ; Oxidative stress ; GFAP ; Sex differences ; Blood&ndash ; brain barrier
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：245-253
- 全文大小：644 K
文摘
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Stroke risk and stroke outcomes are influenced by age and sex.
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Astrocytes play a key role in the brain's response to stroke.
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Sex differences in stroke severity may be related to gonadal hormones acting on/through astrocytes.
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The astrocytic response to ischemia is impaired with aging.
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Epigenetic alterations in astrocytes may underlie worsened outcomes during aging.