Chitinase expression in Alzheimer's disease and non-demented brains regions
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- 作者：C. Sanfilippoa ; L. Malaguarnerab ; M. Di Rosab ; mdirosa@unict.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：CR ; cerebellum ; VC ; visual cortex ; DLPFC ; dorsolateral prefrontal cortex ; EC ; Brodmann's areas ; BA ; entorhinal cortex ; SFG ; superior frontal gyrus ; HIP ; hippocampus ; MTG ; middle temporal gyrus ; PCG ; posterior cingulate cortex ; MeV ; MultiExperiment Viewer ; CHIT1 ; chitotriosidase ; AMcase or CHIA ; acidic mammalian chitinase ; CHI3L1 ; chitinase 3-like-1 ; CHI3L2 ; chitinase 3-like-2 ; CHID1 ; chitinase domain&ndash ; containing 1 ; AD ; Alzheimer disease ; LOAD ; late-onset AD ; Aβ ; amyloid beta ; Aβ42 ; β-amyloi
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：369
- 期：Complete
- 页码：242-249
- 全文大小：1181 K
文摘
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All chitinases genes were modulated in LOAD brain regions compared to healthy subjects.
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Positively correlation was found between chitinases gene expression and healthy age's subjects.
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CHI3L1 and CHI3L2 were regulated differently in healthy and LOAD brain regions depending by the sex.