Characterization of human adipose tissue-derived stem cells in vitro culture and in vivo differentiation in a temperature-sensitive chitosan/β- glycerophosphate/collagen hybrid hydrogel
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- 作者：Kedong Songa ; Kedongsong@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; liying Lia ; Xinyu Yana ; Wen Zhanga ; Yu Zhanga ; Yiwei Wangb ; Tianqing Liua ; liutq@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adipose-derived stem cells ; Chitosan ; Hydrogel ; 3-dimensional fabrication ; Adipogenic differentiation
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：231-240
- 全文大小：2890 K
文摘
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The hydrogel scaffold was produced using chitosan, β-glycerophosphate and collagen.
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This novel hydrogel is in liquid phase at low temperature and is gelatinized at 37 °C.
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The new hydrogel provides ADSCs a favorable 3D environment with highly maintenance of proliferation and cytoactive.
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ADSCs seeded hydrogel differentiated into adipose tissue, indicating favorable ability of adipogenesis.
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This attractive property of C/GP/CO hydrogel points to its value as an excellent scaffold for tissue engineering.