A unique scaffold for bone tissue engineering: An osteogenic combination of graphene oxide-hyaluronic acid-chitosan with simvastatin

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• 作者：Afeesh Rajan Unnithan^a ; ^b ; ^{afeeshnano@gmail.com} ; Arathyram Ramachandra Kurup Sasikala^a ; Chan Hee Park^a ; ^b ; ^{biochan@jbnu.ac.kr} ; Cheol Sang Kim^a ; ^b ; ^{chskim@jbnu.ac.kr}
• 关键词：Graphene oxide ; Chitosan ; Hyaluronic acid ; Simvastatin ; Bone tissue engineering
• 刊名：Journal of Industrial and Engineering Chemistry
• 出版年：2017
• 出版时间：25 February 2017
• 年：2017
• 卷：46
• 期：Complete
• 页码：182-191
• 全文大小：4622 K
• 卷排序：46

文摘

The scaffold can function as a platform for the biomineralization of hydroxyapatite. The presence of simvastatin enhances the osteogenic property of scaffolds. Chitosan (CS)–hyaluronic (HA) acid composite improves the bone formation. Graphene oxide (GO) provides higher mechanical support for GO–CS–HA scaffolds. Biocompatible and osteoinductive scaffold with higher mineralization activity.