O,N-carboxymethyl chitosan–zinc complex: A novel chitosan complex with enhanced antimicrobial activity

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• 作者：Ramchandra L. Patale^a ; Vandana B. Patravale ; ^a ; ^{vbp_muict@yahoo.co.in}
• 关键词：Antimicrobial ; Chitosan&#x2013 ; zinc complex ; O ; N-carboxymethyl chitosan&#x2013 ; zinc complex
• 刊名：Carbohydrate Polymers
• 出版年：2011
• 出版时间：22 April 2011
• 年：2011
• 卷：85
• 期：1
• 页码：105-110
• 全文大小：566 K

文摘

Chitosan is a biodegradable, biocompatible and non-toxic deacetylated derivative of chitin. It exhibits myriad of biological activities such as antithrombogenesis, anti-tumor activity, antimicrobial activity, wound healing activity and blood compatibility. Due to the presence of amine (–NH₂) groups and hydroxyl (–OH) groups, chitosan can be modified to generate various novel derivatives with varying solubility patterns. Among the various derivatives, O,N-carboxymethyl chitosan has been found to elicit broad range of biological activities and proved to be useful in pharmaceutical applications. Chitosan derivatives form co-ordinate complexes with metal ions like zinc and copper which are also known to have antimicrobial activity. In the present investigation, O,N-carboxymethyl chitosan–zinc complex and chitosan–zinc complex were prepared and characterized using FTIR, XRD and DSC. Further, the complexes were evaluated and compared for antimicrobial activities against Gram-positive and Gram-negative bacteria. The studies revealed that the proposed novel O,N-carboxymethyl chitosan–zinc complex exhibited better antimicrobial activity than chitosan–zinc complex.