Acute-on-Chronic Liver Failure (ACLF) in Coastal Eastern India: “A Single-Center Experience”

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• 作者：Girish Kumar Pati ; Ayaskanta Singh ; Bijay Misra ; Debasis Misra ; Haribhakti Seba Das ; Chittaranjan Panda ; Shivaram Prasad Singh ; ^{scb_gastro_dept@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACLF ; acute-on-chronic liver failure ; AD ; acute decompensation ; ALD ; alcoholic liver disease ; ALT ; alanine transaminase ; APASL ; Asian Pacific Association for the Study of the Liver ; CLD ; chronic liver disease ; CTP ; Child-Turcotte-Pugh ; EASL-AASLD ; European Association for the Study of the Liver-American Association for the Study of Liver Diseases ; HBV ; hepatitis B virus ; HE ; hepatic encephalopathy ; HEV ; hepatitis E virus ; HRS ; hepatorenal syndrome ; INR ; International Normalized Ratio ; MELD ; Mode
• 刊名：Journal of Clinical and Experimental Hepatology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：6
• 期：1
• 页码：26-32
• 全文大小：312 K

文摘

Acute-On-Chronic liver failure (ACLF) is an emerging entity. The present study was undertaken to analyze the clinical profile and natural course of ACLF patients.

Patients and methods

ACLF was defined as per Asia Pacific Association for the Study of Liver consensus criteria 2009. Patients fulfilling these criteria with some deviations were included and prospectively evaluated for clinical profile, etiologies of acute decompensation (AD) and underlying chronic liver disease, and short-term natural course [3 months].

Results

Out of 123 patients with ACLF (mean age: 45.83 ± 12.05 years; male:female 109:14), 45.53% cases had prior history of AD, and 54.47% presented for the first time as ACLF. Etiologies of cirrhosis were alcohol, cryptogenic, and chronic hepatitis B virus infection in 65.04%, 23.57%, and 11.38% cases, respectively. Recent history of alcohol intake (within 4 weeks) [42.27%] followed by bacterial infections [36.58%] were the common etiologic precipitants for AD. Only 87 (70.73%) out of 123 cases could be followed up for a duration of 3 months; 62 (71.26%) cases died by 3 months. Most deaths occurred in the alcoholics compared to nonalcoholics [(43/53) 81.13% vs. (19/34) 55.88%; P = 0.01]. No significant difference in mortality rate was observed between ACLF cases with history of prior AD compared to newly diagnosed ACLF cases [30/40 (75%) vs. 32/47 (68.09%); P = 0.477]. The prognostic markers [MELD, MELD-Na, CTP] were not significantly different between survivors and nonsurvivors.

Conclusion

ACLF patients in our population had high short-term mortality rates with majority of deaths in alcoholics. Alcohol intake and bacterial infections were mainly responsible for AD in our study.