An LRR-only protein representing a new type of pattern recognition receptor in Chlamys farreri
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- 作者：Mengqiang Wanga ; Lingling Wanga ; c ; wanglingling@ms.qdio.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Ying Guoa ; Qilin Yib ; Linsheng Songb
- 关键词：Chlamys farreri ; Innate immunity ; Leucine-rich repeat ; LRR-only protein ; Pattern recognition receptor
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：1
- 页码：145-155
- 全文大小：2327 K
文摘
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An LRR-only protein gene was cloned from scallop Chlamys farreri.
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Its mRNA transcripts in haemocytes increased after PAMP stimulations.
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CfLRRop-1 exhibited binding activity to various PAMPs.
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The mRNA expression level of CfLRRop-1 was up-regulated when CfTLR was suppressed.
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CfLRRop-1 induced release of TNF-伪 from mixed primary cultured scallop haemocytes.