The sequence variation and functional differentiation of CRDs in a scallop multiple CRDs containing lectin

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• 作者：Mengmeng Huang^a ; Lingling Wang^b ; Huan Zhang^c ; Chuanyan Yang^b ; Rui Liu^c ; Jiachao Xu^c ; Zhihao Jia^c ; Linsheng Song^b ; ^{lshsong@qdio.ac.cn}
• 关键词：Chlamys farreri ; C-type lectin ; Carbohydrate-recognition domain ; Ca2+ binding site 2 ; Functional differentiation
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：333-339
• 全文大小：1391 K
• 卷排序：67

文摘

The sequences of Ca2+-binding site 2 in CRDs of CfLec-4 were diversified. Functional differentiation was observed among the CRDs of CfLec-4. CRD3 and CRD4 were the dominant CRDs for CfLec-4's PAMP recognition. CRD1, CRD3 and CRD4 contributed mainly for opsonization triggered by CfLec-4.