Towards optimized anesthesia protocols for stereotactic surgery in rats: Analgesic, stress and general health effects of injectable anesthetics. A comparison of a recommended complete reversal anesthesia with traditional chloral hydrate monoanesthesia
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- 作者：Christin Hü ; skea ; Svenja Esther Sanderb ; svenja.sander@fu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Melanie Hamannc ; Olivia Kershawd ; Franziska Richtera ; Angelika Richtera
- 关键词：A ; adrenaline ; CH ; chloral hydrate ; HR ; heart rate ; iCs ; immunoreactive corticosterone ; LORR ; loss of righting reflex ; MMF ; complete reversal anesthesia ; MMF+R ; complete reversal anesthesia with reversal ; NA ; noradrenaline ; RR ; respiratory rate ; spO2 ; saturation level ; ST ; surgical tolerance
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：1642
- 期：Complete
- 页码：364-375
- 全文大小：1451 K
文摘
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Suitability of reversal anesthesia (MMF) was compared with chloral hydrate.
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Chloral hydrate cannot be recommended due to pronounced systemic toxicity.
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MMF led to local myositis and exophthalmos, which limits its use in research.
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Reversal of MMF caused undesired effects.
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Rodent anesthesia has to be assessed by subjective and objective parameters.