Role of potassium channels in chlorogenic acid-induced apoptotic volume decrease and cell cycle arrest in Candida albicans

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• 作者：JiEun Yun ; Dong Gun Lee ; ^{dglee222@knu.ac.kr}
• 关键词：AVD ; apoptotic volume decrease ; CRA ; chlorogenic acid ; DIDS ; 4 ; 4&prime ; -diisothiocyanatostilbene-2 ; 2&prime ; -disulfonic acid disodium salt ; TEA ; tetraethylammonium chloride
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1861
• 期：3
• 页码：585-592
• 全文大小：968 K
• 卷排序：1861

文摘

Chlorogenic acid (CRA) induces apoptosis in Candida albicans. CRA induces potassium efflux leading to apoptotic volume decrease. Block of the potassium channels inhibits the apoptotic effect of CRA. Potassium channels play a key role in regulation of the CRA-induced apoptosis.