The stellate vascular smooth muscle cell phenotype is induced by IL-1尾 via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation
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- 作者：Karl Blirandoa ; Ré ; gis Blaisea ; Natalia Gorodnayaa ; Clotilde Rouxela ; Olivier Meilhacb ; Pierre Vincenta ; Isabelle Limona ; isabelle.limon@upmc.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：6-BNZ ; N6-benzoyladenosine-3&prime ; 5&prime ; -cyclic monophosphate ; 8-pCPT-O-Me-cAMP ; 8-(4-chlorophenylthio)-2&prime ; -O-methyladenosine-3&prime ; 5&prime ; -cyclic monophosphate sodium salt ; ApoE ; apolipoprotein E ; cAMP ; cyclic adenosine monophosphate ; CCL3 or MIP-1伪 ; chemokine (C&ndash ; C motif) ligand 3 ; CCL5 or RANTES ; chemokine (C&ndash ; C motif) ligand 5 ; CCL18 or PARC ; chemokine (C&ndash ; C motif) ligand 18 ; CFP ; cyan fluorescent protein ; COX-2 ; cyclooxygenase-2 ; CX3CL1 or fraktalkin ; chemokine
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：1853
- 期：12
- 页码：3235-3247
- 全文大小：3019 K
文摘
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VSMCs transit from a contractile to a stellate morphology upon IL-1尾 stimulation.
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The IL-1尾 effect on VSMC morphology is indirect and due to the secretion of the PGE2.
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Binding to EP4, PGE2 stimulates cAMP production and PKA, modifying cell structure.
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20">Silencing PKAR1伪 -but not R1尾-mimicked the effect of IL-1尾/PGE2 on cell morphology.