PGE2 released by primary sensory neurons modulates Toll-like receptor 4 activities through an EP4 receptor-dependent process
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- 作者：Kai-Hei Tse ; frankitse@ust.hk" class="auth_mail" title="E-mail the corresponding author ; Kevin B.S. Chow ; Helen Wise
- 关键词：6-Bnz-cAMP ; N6-benzoyladenosine-3&prime ; 5&prime ; cyclic monophosphate ; COX ; cyclooxygenase ; 8-pCPT ; 8-(4-chlorophenylthio)-2&prime ; -O-methyladenosine-3&prime ; -5&prime ; -cyclic monophosphate ; DAMPS ; danger-associated molecular patterns ; DRG ; dorsal root ganglion ; EGFR ; epidermal growth factor receptor ; EIA ; enzyme immunoassay ; EP ; prostaglandin E2 receptor subtype ; EPAC ; guanine nucleotide exchange factor ; GFAP ; glial fibrillary acidic protein ; GS ; glutamine synthetase ; IL-1β ; interleukin 1β ; IP
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：8-16
- 全文大小：1258 K
文摘
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In DRG cells, physiological level of PGE2 inhibits LPS-stimulated TNFα via EP4 receptors.
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LPS-stimulated COX-2 and TNFα are auto-inhibited by endogenous PGE2 via EP4 receptors.
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DRG neurons endogenously produce COX-2-derived PGE2 to regulate TLR4 activity in glia.