Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells

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• 作者：Hyun Jin Park ; Yong Jun Choi ; Jeong Hyun Lee ; Myeong Jin Nam ; ^{genetx@hanmail.net}
• 关键词：Naringenin ; Pancreatic cancer ; Peroxiredoxin-1 ; Reactive oxygen species ; Apoptosis signal-regulation kinase 1
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：1-8
• 全文大小：1985 K
• 卷排序：99

文摘

Naringenin induces apoptosis in human pancreatic cancer SNU-213 cells. Naringenin suppresses expression of peroxiredoxin-1 in SNU-213 cells. Naringenin increases intercellular ROS level. Naringenin activates ASK1, JNK, p38 and p53 proteins in SNU-213 cells. Naringenin causes ASK1-induced apoptosis mediated by ROS.