Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy
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- 作者：Jing-Bo Yanga ; 1 ; yjingb@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yin-Hu Wanga ; 1 ; wangyh8@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Yanga ; ywei0702@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fang-Ting Lua ; fangting@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hong-Di Maa ; mahongdi@ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhi-Bin Zhaoa ; zzbin@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yan-Jie Jiaa ; jyanjie@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Tanga ; wayne012@mail.ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Koichi Tsuneyamab ; tsuneyama.koichi@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; William M. Ridgwayc ; ridgwawm@uc.edu" class="auth_mail" title="E-mail the corresponding author ; M. Eric Gershwind ; megershwin@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author ; Zhe-Xiong Liana ; e ; zxlian1@ustc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Primary biliary cirrhosis ; Cholangitis ; CD4+ T cells ; Regulatory T cells ; Bone marrow chimeric mice ; Parabiosis
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：108-117
- 全文大小：4081 K
文摘
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Emphasized the necessity of CD4 T cells in the pathology of primary biliary cirrhosis using CD4−/−Tg mice.
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Tregs in dnTGFβRII mice have impaired suppression to CD8 T cells compared to WT Tregs.
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Replace the CD4 T cells lineage by parabiosis can successfully reverse biliary disease.
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Replace the CD4 T cells lineage by bone marrow reconstitution can help protecting cholangitis.