Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients
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- 作者：Thomas D. Dayspring ; MD ; FACP ; FNLAa ; b ; tdayspring@aol.com" class="auth_mail" title="E-mail the corresponding author ; Stephen A. Varvel ; PhDb ; Leila Ghaedi ; PhDb ; Dawn L. Thiselton ; PhDb ; James Bruton ; MSb ; Joseph P. McConnell ; PhD ; DABCCb
- 关键词：Cholesterol homeostasis ; Sitosterol ; Campesterol ; Cholestanol ; Desmosterol ; APOE genotype
- 刊名：Journal of Clinical Lipidology
- 出版年：2015
- 出版时间：November-December 2015
- 年：2015
- 卷：9
- 期：6
- 页码：807-816
- 全文大小：1022 K
文摘
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Large cohort study of a clinical laboratory database comprising 667,718 patients.
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Described sample distributions of cholesterol absorption and/or synthesis biomarkers.
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Circulating noncholesterol and/or stanol biomarker levels are affected by age and sex.
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Levels of cholesterol absorption markers are elevated in APOE ε4 allele carriers.
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These data may facilitate clinical research efforts and personalization of therapy.