SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma
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- 作者：Hiart Navarro-Imaz ; Yuri Rueda ; Olatz Fresnedo
- 关键词：ACAT ; acyl-coenzyme A ; cholesterol acyltransferase ; CD ; cyclodextrin ; CE ; cholesteryl ester ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; FC ; free cholesterol ; HCC ; hepatocellular carcinoma ; HMGCR ; hydroxymethylglutaryl-coenzyme A reductase ; INSIG ; insulin induced gene ; LD ; lipid droplet ; LDL ; low density lipoprotein ; NBD ; 4-chloro-7-nitrobenzofurazan ; PPAR ; peroxisome proliferator activated receptor ; SCAP ; SREBP cleavage activating protein ; SND1 ; Staphylococcal nuclease domain-containing
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：988-996
- 全文大小：1356 K
文摘
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SND1-overexpressing hepatoma cells accumulate de novo synthesised cholesteryl esters.
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SND1-overexpression overrides LDL-induced cholesterogenesis inhibition.
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SND1 modulates regulatory cholesterol pools in the endoplasmic reticulum.
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SND1 increases SREBP2 proteolytic activation and turnover.
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SND1 overexpression sensitizes hepatoma cells to saponin permeabilization.