Components characterization of total tetraploid jiaogulan (Gynostemma pentaphyllum) saponin and its cholesterol-lowering properties
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- 作者：Jie Liua ; b ; Yanfang Lia ; Haiming Shia ; Thomas Wangc ; Xianli Wud ; Xiangjun Suna ; xjsun@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liangli (Lucy) Yua ; e ; yu5@umd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP7A1 ; cholesterol-7α-hydroxylase ; ABCG5/8 ; ATP-binding cassette transporter subfamily G members 5/8 ; LXRα ; liver X receptor alpha ; TC ; total cholesterol ; TG ; triacylglycerols ; LDL-C ; low-density lipoprotein cholesterol ; HDL-C ; high-density lipoprotein cholesterol ; NPC1L1 ; Niemann-Pick C1-like 1 protein ; ACAT2 ; asacyl CoA ; cholesterol acyltransferase 2 ; CE ; cholesteryl ester ; MTP ; microsomal triacylglycerols transport protein ; LDL-R ; low-density lipoprotein receptor ; ORO ; oil- red O ; TJS ; total
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：542-555
- 全文大小：1815 K
文摘
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Nine saponins, including five reported for the first time, were obtained from tetraploid jiaogulan.
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Total saponins (TJS) reduce plasma cholesterol by modulating intestinal gene expressions of transporters and enzymes.
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TJS modulated hepatic cholesterol homeostasis by promoting expression of genes for bile acids synthesis and excretion.
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TJS lower plasma cholesterol through suppressing intestinal absorption by inhibiting micellar solubilization in intestine.