Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism
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- 作者：Vinay Sachdeva ; Christina Leopolda ; Raimund Bauera ; b ; Jay V. Patankara ; c ; Jahangir Iqbald ; Sascha Obrowskya ; Renze Boverhofe ; Marcela Doktorovae ; Bernhard Scheicherf ; Madeleine Goeritzera ; Dagmar Kolbg ; Andrew V. Turnbullh ; Andreas Zimmerf ; Gerald Hoefleri ; M. Mahmood Hussaind ; Albert K. Groene ; Dagmar Kratkya ; dagmar.kratky@medunigraz.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACAT ; acyl-CoA ; cholesterol acyltransferase ; ApoE ; apolipoprotein E ; DGAT ; acyl-CoA ; diacylglycerol acyltransferase ; I-DGAT1 ; intestine-specific ; Inh-DGAT1 ; DGAT1 inhibitor-treated ; GLP-1 ; glucagon-like peptide 1 ; HF/HCD ; high-fat/high-cholesterol diet ; MTP ; microsomal triglyceride transfer protein ; NLS ; neutral sterol loss ; TICE ; trans-intestinal cholesterol excretion
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：1132-1141
- 全文大小：1506 K
文摘
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Loss of the triglyceride synthesizing enzyme DGAT1 alters cholesterol metabolism.
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Reduced cholesterol absorption by intestine-specific DGAT1 deficiency
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Increased neutral sterol loss upon DGAT1 deficiency/inhibition
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Smaller post-prandial chylomicrons circulate less cholesterol.
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DGAT1 inhibition leads to increased trans-intestinal cholesterol excretion.