HDL functionality in reverse cholesterol transport — Challenges in translating data emerging from mouse models to human disease
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- 作者：Miriam Lee-Rueckerta ; miriam.lee@wri.fi" class="auth_mail" title="E-mail the corresponding author ; Joan Carles Escola-Gilb ; Petri T. Kovanena ; petri.kovanen@wri.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC ; ATP-binding cassette transporter ; Apo ; apolipoprotein ; apobec1 ; apoB mRNA editing enzyme ; ASBT ; apical sodium-dependent bile acid transporter ; BA ; bile acids ; BAT ; bile acid CoA ; amino acid N-acyltransferase ; BSEP ; bile salt export pump ; CEC ; cholesterol efflux capacity ; CETP ; cholesteryl ester transfer protein ; CHD ; coronary heart disease ; cAMP ; cyclic adenosine monophosphate ; CYP7A1 ; cytochrome p450 enzyme cholesterol 7α-hydroxylase ; EL ; endothelial lipase ; FH ; familiar hypercholesterolemi
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1861
- 期：7
- 页码：566-583
- 全文大小：997 K
文摘
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HDL plays a key role in the initiation of the reverse cholesterol transport pathway.
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Mouse models are widely used to study regulation of this pathway.
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We compared HDL metabolism and reverse cholesterol transport between mice and humans.
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HDL-cholesterol levels and HDL metabolism substantially differ between the 2 species.
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Understanding the species-specific differences is critical for translation of data.