Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages
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- 作者：Natalie Fourniera ; b ; natalie_fournier@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; Sylviane Tardivela ; Jean-Franç ; ois Benoistc ; Benoî ; t Vedieb ; Delphine Rousseau-Ralliardd ; Maxime Nowaka ; Fatima Allaouia ; Jean-Louis Paula ; b
- 关键词：AA ; arachidonic acid ; ABCA1 ; ATP-binding cassette transporter A1 ; AC ; adenylate cyclase ; apo ; apolipoprotein ; cAMP ; cyclic AMP ; CE ; cholesteryl esters ; CHD ; coronary heart disease ; DHA ; docosahexaenoic acid ; DPA ; docosapentaenoic acid ; EPA ; eicosapentaenoic acid ; FC ; free cholesterol ; HMDM ; human monocyte-derived macrophages ; LXR/RXR ; liver X receptor/retinoid X receptor ; PDE ; cyclic phosphodiesterase ; PKA ; protein kinase A ; PL ; phospholipids ; PUFA ; polyunsaturated fatty acids ; SM ; sphingomyelin
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1861
- 期：4
- 页码：331-341
- 全文大小：993 K
文摘
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Diet high in n-3/n-6 polyunsaturated fatty acids (PUFA) ratio is cardioprotective.
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We studied the impact of PUFA membrane incorporation on ABCA1 cholesterol efflux pathway.
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Results differ between mouse macrophages (J774) and primary human macrophages (HMDM).
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Eicosapentaenoic acid (EPA) reduced the ABCA1 function in both models and this effect is PKA-dependent in HMDM.