Cholinergic deafferentation of the hippocampus causes non-temporally graded retrograde amnesia in an odor discrimination task
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- 作者：Jenny R. Kö ; ppena ; Sarah L. Stuebinga ; Megan L. Siega ; Ashley A. Blackwella ; Philip A. Blankenshipa ; Joseph L. Cheatwoodb ; Douglas G. Wallacea ; dwallace@niu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Retrograde amnesia ; Septohippocampal cholinergic system ; String pulling ; Mnemonic function ; Odor discrimination
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：299
- 期：Complete
- 页码：97-104
- 全文大小：902 K
文摘
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Infusion of 192-IgG-Saporin into the medial septum significantly reduced cholinergic input into the hippocampus.
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Removal of cholinergic projections from the medial septum produced retrograde amnesia, but there was no evidence for a temporal gradient.
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Infusion of 192-IgG-Saporin into the medial septum did not produce anterograde amnesia.
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Using the string pulling task, mnemonic function can be evaluated, and may allow for the development of therapeutic assessment for neurodegenerative disorders.