Both pre- and post-synaptic alterations contribute to aberrant cholinergic transmission in superior cervical ganglia of APP−/− mice
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- 作者：Zhao-Lin Caia ; 1 ; Jia-Jia Zhanga ; 1 ; Ming Chena ; Jin-Zhao Wanga ; Peng Xiaoa ; Li Yangb ; c ; d ; e ; yangli08@scnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Cheng Longa ; c ; longcheng@scnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid precursor protein ; Superior cervical ganglia ; Cholinergic synaptic transmission ; High-affinity choline transporter ; Nicotinic acetylcholine receptor
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：493-502
- 全文大小：2394 K
文摘
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APP is required to maintain cholinergic synaptic transmission in SCG.
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APP preserves repetitive cholinergic neurotransmission by presynaptic CHT.
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APP contributes to postsynaptic function by assisting α4β2 and α7 nAChRs.
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APP protects synaptic structure in presynaptic vesicle pool and PSD length.