Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors
详细信息 查看全文
- 作者：Xueyan Panga ; b ; Liwang Liua ; Jennifer Ngolaba ; b ; Rubing Zhao-Sheaa ; J. Michael McIntoshc ; d ; e ; Paul D. Gardnera ; b ; Andrew R. Tappera ; b ; andrew.tapper@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetylcholine ; Habenula ; Nicotine ; Withdrawal ; Anxiety
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：294-304
- 全文大小：1837 K
文摘
- •
Nicotinic receptors expressed in habenula cholinergic neurons modulate anxiety.
- •
Chronic nicotine functionally upregulates α6* nicotinic receptors in medial habenula.
- •
Blocking medial habenula α6* nicotinic receptors reduces nicotine withdrawal anxiety.