Dose-dependent effect of donepezil administration on long-term enhancement of visually evoked potentials and cholinergic receptor overexpression in rat visual cortex

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• 作者：Mira Chamoun¹ ; Marianne Groleau¹ ; Menakshi Bhat ; Elvire Vaucher ; ^{elvire.vaucher@umontreal.ca}
• 关键词：Cholinergic enhancement ; Acetylcholinesterase inhibitors ; Cortical activity ; Muscarinic receptors ; Nicotinic receptors ; Visual cortex
• 刊名：Journal of Physiology-Paris
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：110
• 期：1-2
• 页码：65-74
• 全文大小：775 K
• 卷排序：110

文摘

The cholinergic potentiation of visual training enhances long-term responses in V1. The cholinergic potentiation of visual training triggers AChR subtypes upregulation. A high dose of donepezil elicits stronger and broader effects than a low dose. Donepezil use could be implemented to visual rehabilitation in human.