A new bi-layered scaffold for osteochondral tissue regeneration: In vitro and in vivo preclinical investigations
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- 作者：M. Sartoria ; S. Paganib ; stefania.pagani@ior.it" class="auth_mail" title="E-mail the corresponding author ; A. Ferrarib ; c ; V. Costad ; V. Carinad ; E. Figalloe ; M.C. Maltarellof ; L. Martinib ; M. Finib ; G. Giavaresid
- 关键词：Osteochondral lesion ; Biomimetic ; Bi-layered scaffold ; Collagen I ; Magnesium-doped hydroxyapatite ; Molecular biology ; Animal model ; Implant ; Histology
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：101-111
- 全文大小：2004 K
文摘
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Osteochondral lesions are still lacking of definitive and satisfactory solutions.
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A new bilayered scaffold able to support bone and cartilage regeneration is proposed.
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Type I collagen, Mg-doped hydroxyapatite and adequate crosslinking as novelty
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In vitro and in vivo (heterotopic implant in nude mice) assessments are reported.